A Practical Route to Substituted 7-Aminoindoles from Pyrrole-3-carboxaldehydes
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چکیده
منابع مشابه
A Practical Route to Substituted 7-Aminoindoles from Pyrrole-3-carboxaldehydes
Among privileged structures, indoles occupy a central place in medicinal chemistry and alkaloid research. Here we report a flexible and efficient conversion of pyrrole-3-carboxaldehydes to substituted 7-amino-5-cyanoindoles. Phosphine addition to fumaronitrile proceeds with prototropic rearrangement of the initially formed zwitterion to the thermodynamically favored phosphonium ylide, which is ...
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2014
ISSN: 1523-7060,1523-7052
DOI: 10.1021/ol503078h